Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran

J Med Chem. 1994 Aug 5;37(16):2506-8. doi: 10.1021/jm00042a002.
No abstract available

MeSH terms

  • Crystallography, X-Ray
  • Drug Design*
  • Furans / chemistry*
  • Furans / metabolism
  • Furans / pharmacology
  • HIV Protease / metabolism
  • HIV Protease Inhibitors / chemistry*
  • HIV Protease Inhibitors / metabolism
  • HIV-1 / drug effects
  • HIV-1 / enzymology*
  • Hydrogen Bonding
  • Isoquinolines / chemistry
  • Isoquinolines / metabolism
  • Isoquinolines / pharmacology
  • Models, Molecular
  • Molecular Structure
  • Quinolines / chemistry
  • Quinolines / metabolism
  • Saquinavir

Substances

  • Furans
  • HIV Protease Inhibitors
  • Isoquinolines
  • Quinolines
  • L 739594
  • tetrahydrofuran
  • HIV Protease
  • Saquinavir